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The Zhu Lab
Immunoengineering & Immunomodulation
Immunoengineering focuses on designing, developing, and manipulating the immune system's components to diagnose, monitor, and treat diseases. It involves the integration of engineering principles with immunology to create innovative tools and therapies that can modify immune responses in precise and controlled ways. Immunomodulation refers to the therapeutic manipulation of the immune system to achieve a desired immunological response. The goal of immunomodulation is to enhance or suppress the immune system to prevent, treat, or cure diseases.
Biomaterials-based Immunomodulation
We are developing innovative medical implants engineered to modulate immune reactions in beneficial ways. Our goal is to minimize adverse immune responses, such as inflammation and rejection, while promoting beneficial outcomes like healing and tissue integration.
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AI-assisted Immunomodulatory Drugs
Our research focuses on AI-assisted therapeutics to modulate immune system activity in aging and dementia. We apply AI-driven approaches to identify targets, guide therapeutic design, and predict treatment responses, enabling more precise control of immune pathways. A central focus is the regulation of inflammaging, the chronic low-grade inflammation associated with aging. We investigate these mechanisms across diseases including Alzheimer's disease, Multiple sclerosis, Arthritis, and Osteoporosis to develop targeted immunomodulatory therapies.

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